High-resolution Imaging of Corneal Lesions With Optical Coherence Tomography (OCT) - A Pilot Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01753583

Enrollment

Registered

2012-12-20

Start date

2013-07-23

Completion date

2016-03-01

Last updated

2020-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Corneal Abrasions, Corneal Infiltrates

Keywords

optical coherence tomography, corneal abrasion, corneal infiltrate

Brief summary

Corneal lesions such as corneal abrasions and corneal infiltrates are common in clinical practice. The current study seeks to investigate whether high-resolution OCT is suitable for imaging of these corneal lesions. The present study has the character of a pilot study and the results are intended to be used to develop a standardized protocol for imaging and analysis of these corneal lesions. Based on this protocol, further studies investigating the pathophysiology of corneal lesions or evaluating therapeutic success can be planned.

Interventions

DEVICEOptical Coherence Tomography (OCT)

High-resolution OCT imaging of the cornea

OTHERSlit lamp biomicroscopy

Slit lamp biomicroscopy with fluorescein staining and slit lamp photograph

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Men and women aged over 18 years * Newly diagnosed corneal abrasion or corneal infiltrate

Exclusion criteria

* Recurrent corneal erosion * Participation in a clinical trial in the previous 3 weeks * Presence of any abnormalities preventing reliable measurements as judged by the investigator * Any contraindication for topical application of Novain 0.4% eye drops for topical anesthesia or of Minims-Fluorescein Sodium eye drops for fluorescein staining * Pregnancy, planned pregnancy or lactating

Design outcomes

Primary

Measure	Time frame	Description
Imaging of corneal abrasions and infiltrates	1 day	The aim of this pilot study is to investigate whether imaging of these corneal alterations is possible.

Secondary

Measure	Time frame	Description
Size and depth of corneal lesions as assessed with high-resolution OCT	1 day	The volume and size of corneal lesions or infiltrates will be assessed using a specific software.
Slit lamp biomicroscopy with fluorescein staining	1 day	The volume and size of corneal lesions or infiltrates will be assessed.

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026