Kidney Transplant Recipient
Conditions
Keywords
multidetector coronary CT angiography, renal transplantation
Brief summary
The aim of this study is to evaluate the clinical usefulness of 64-slice multidetector coronary CT angiography (MDCTA) in renal transplant recipients who had no previous coronary artery disease (CAD). Primary endpoint is to assess the prevalence and severity of coronary artery disease in patients post-transplant 6 to 12 months. CAD can be diagnosed noninvasively with similar accuracy of coronary angiography using MDCTA. Early detection and intervention of CAD may provide survival benefit in renal transplant recipients.
Interventions
OTHER64-slice Multidetector coronary CT angiography
Sponsors
Yonsei University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. age ≥ 40 yrs 2. renal transplant recipient at post-transplant 6 to 12 months 3. stable graft renal function: CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation ≥45 mL/min/1.75m2 4. patients who had no previous CAD
Exclusion criteria
1. unstable graft renal function 2. History of acute kidney injury within 3 months 3. Allergic history to contrast agent 4. Irregular heart beat 5. Multiorgan transplant recipients 6. Pregnancy 7. Patients who do not consent to this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| prevalence of coronary artery disease | at post-transplant 6 to 12 months. |
Secondary
| Measure | Time frame |
|---|---|
| severity of coronary artery disease | at post-transplant 6 to 12 months |
Countries
South Korea
Outcome results
None listed