Assessment of the Relative Increase in Bioavailability of (Non-) Nutrients From a Mixed Salad by Adding Fat Containing Dressing

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01752764

Enrollment

Registered

2012-12-19

Start date

2013-04-30

Completion date

2013-12-31

Last updated

2014-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Subjects

Brief summary

The hypothesis will be tested that fat can also increase absorption of (non)-nutrients from a salad. Therefore we designed the current study to show an increase in relative absorption (bioavailability) of (non-) nutrients from a mixed salad by adding fat containing dressing.

Interventions

OTHERTest product: Salad with a high dosage fat

OTHERControl product: Salad with low dosage fat

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

Main inclusion Criteria: * Body mass index (BMI) ≥ 18.5 and ≤ 30.0 kg/m2. * Apparently healthy: no medical conditions, no use of prescribed or over the counter drugs, which might affect study measurements (as judged by study physician) * Haemoglobin within normal reference range as judged by the study physician. * Total cholesterol, LDL cholesterol, HDL cholesterol and fasting triglycerides within the normal reference range, as judged by the study physician. Main

Exclusion criteria

* Reported use of any medically- or self-prescribed diet at the moment of screening, or the intention to use any kind of diet in the period between screening and the end of the study. * Reported weight loss or gain ≥ 10 % of bodyweight during a period of six months before screening. * A known food allergy or intolerance. * A dislike to the foods supplied during the study. * Use of vitamins or supplements enriched with carotenoid and/or vitamin A and/of vitamin K. * Known hypothyroidism or hyperthyroidism.

Design outcomes

Primary

Measure	Time frame	Description
Area under the curve (AUC in nmol/l*h) of (non) nutrients	July 2013	Area under the curve (AUC in nmol/l\*h) of (non) nutrients. The AUCs are constructed from (non-) nutrient levels measured in plasma chylomicrons at the selected time-points. The size of the areas under the curves will be compared between the test and control dressing.

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026