Acetazolamide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow

Basic Research on Acetazolamide´s Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow in a Humane Experimental Headache Model

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01750723

Enrollment

Registered

2012-12-17

Start date

2012-12-31

Completion date

2013-04-30

Last updated

2013-07-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Headache, Migraine

Keywords

Acetazolamide, Headache, Migraine

Brief summary

In this study the investigators will research the hypothesis that the drug Acetazolamide induce headache and dilation of cerebral arteries and increase the cerebral blood flow in the areas of the brain supplied by these arteries.

Detailed description

To investigate headache score and accompanying symptoms during and after infusion of acetazolamide. With magnetic resonance imaging the investigators will investigate changes in regional cerebral blood flow (rCBF) in the area supplied by middle cerebral artery (MCA), diameter of MCA, the Internal carotic artery (ICA), the superficial temporal artery (STA) and the Medial Meningeal artery (MMA).

Interventions

DRUGAcetazolamide

1 g diluted in 10 ml saline, i.v. bolus injection.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy volunteers * Aged 18-40 * 50-100 kg * Fertile women must use safe contraceptives (IUD, oral contraceptives, surgical sterilisation and long lasting gestagen.

Exclusion criteria

* Tension type headache more than once/month * Other primary headaches * Daily medication except contraceptives * Drug taken within 4 times the halflife for the specific drug except contraceptives * Pregnant or lactating women * Exposure to radiation within the last year * Headache within the last 24 hours before start of trial * Hypertension * Hypotension * Respiratory or cardiac disease

Design outcomes

Primary

Measure	Time frame	Description
Headache scores	24 h	Comparison between Acetazolamide and placebo (saline).

Secondary

Measure	Time frame	Description
Artery circumference	Baseline, 30 min and 60 min	Acetazolamide induced changes in intracranial artery circumference before and after infusions.
Cerebral blood flow	Baseline, 30 and 60 min.	Acetazolamide induced changes in cerebral blood flow.

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026