Nutritional Status at the Release of ICU.
Conditions
Keywords
ICU, Body composition, Nutrition, Survival, Morbidity
Brief summary
It is established that the surviving patients after a stay in the ICU are characterized by frequent malnutrition and morbidity and mortality. The main goal of this work is to study the relationship between nutritional statuses during ICU hospitalization, whatever its determinants, and quality of life, morbidity and mortality at one year. The hypothesis of the study is that the presence of under nutrition is responsible for a 10% increase in crude mortality at one year (which would be respectively 30% for malnourished patients and 20% for non-malnourished patients).
Detailed description
This is a multicenter cohort study of a 30-month follow-up on patients after a stay in ICU. Nutritional parameters and evaluation of the quality of life will be collected during hospitalization and output during a visit to the Clinical Research Associate at 6 months and one year. Survival will be also noted. These parameters will be studied in comparative patients malnourished and non-malnourished.
Interventions
None listed
Sponsors
Société des Produits Nestlé (SPN)
Baxter S.A.S
University Hospital, Strasbourg, France
Hospices Civils de Lyon
University Hospital, Clermont-Ferrand
Study design
Observational model
COHORT
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients of both sexes, age greater than or equal to 18 years * Hospitalized more than 72 hours in the ICU * Requiring at least one support organ failure: 1. Ventilatory support (invasive or noninvasive) 2. Administration of catecholamines 3. Extrarenal purification whatever technique * Affiliated to a social security system * Having given free, informed written consent
Exclusion criteria
* Patients with end-stage disease or for which a limitation of care was decided * Pregnant women * Patients with minor or under guardianship * Incapacitated adults and psychiatric inpatients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| all-cause mortality | at one year |
Secondary
| Measure | Time frame |
|---|---|
| Post-traumatic stress | at inclusion, M6 and M12 |
| Quality of life | at M6 and M12 |
| Degree of activity (Karnofsky questionnaire) | At M6 and M12 |
| Weight | at inclusion, M6 and M12 |
| Anxiety and depression | at inclusion, M6 and M12 |
| Albumin | at inclusion, M6 and M12 |
| Orosomucoid | at inclusion, M6 and M12 |
| Transthyretin (prealbumin) | at inclusion, M6 and M12 |
| Body composition | at inclusion, M6 and M12 |
| Body mass index | at inclusion, M6 and M12 |
Countries
France
Contacts
Primary ContactPatrick LACARIN
Outcome results
None listed