Subcapsular Orchiectomy in Men With Klinefelter Syndrome

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01750632

Enrollment

Registered

2012-12-17

Start date

2010-08-31

Completion date

2014-12-31

Last updated

2016-10-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Klinefelter Syndrome

Brief summary

Men with Klinefelter syndrome undergo unilateral subcapsular ochiectomy, and the removed testicular tissue is examined for presence of sperm and cryopreserved in small pieces for fertility treatment and scientific purposes. Prior to operation blood samples are frozen in a biobank.

Interventions

PROCEDUREOrchiectomy

The patients undergo subcapsular orchiectomy with basic surgical instruments. The patients are given local analgesia and sometimes universal anesthesia.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

15 Years to 40 Years

Healthy volunteers

Inclusion criteria

* Klinefelter * 15-40 years of age

Exclusion criteria

* inability to understand the study

Design outcomes

Primary

Measure	Time frame
Presence of testicular sperm	Between 1 and 6 months

Secondary

Measure	Time frame
Clinical pregnancy rate after ICSI with retrieved testicular sperm	participants will be followed for the duration of fertility treatment, an expected average of 6 months

Other

Measure	Time frame
Predictive value of FSH and other hormones for the presence of testicular sperm	Between 1 and 6 months

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026