Study on Correlation Between Vascular ET-1 and Adiponectin in Pediatric Obesity

Observational Retrospective Study on Correlation Between ET-1 and Ad in Obese Children

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01750333

Enrollment

Registered

2012-12-17

Start date

2012-04-30

Completion date

2013-03-31

Last updated

2012-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endothelial Dysfunction, Insulin Resistance, OBESITY

Brief summary

The aim of this study is to explore whether and how high circulating levels of endothelin-1 (ET-1) in obese and overweight children may contribute to impair adiponectin (Ad) production, release and vascular activity

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

5 Years to 13 Years

Healthy volunteers

Inclusion criteria

* Children will be enrolled into lean, overweight or obese groups based on Body mass index (BMI) calculated according to standard methods. International standards for sex-and age-specific BMI centiles for subjects aged 2-18 years will be used. The 95th centile of BMI reference is the cut off point for childhood obesity. Overweight and obese children are defined as those with a BMI higher than the centile curves.

Exclusion criteria

* presence of renal, liver and/or cardiovascular diseases; * hypertension; * metabolic and/or endocrine disorders; * genetic syndromes; * histories of chronic allergies, acute infectious or inflammatory diseases during the last 3 months preceding the study

Design outcomes

Primary

Measure	Time frame
Correlation between serum levels of ET-1 and Ad in lean, overweight and obese children	12 months

Countries

Italy

Outcome results