Breast Diseases
Conditions
Keywords
Breast diseases, magnetic resonance spectroscopy
Brief summary
To delineate if the chemical composition (lipid and water) in the presumably normal breast of the high risk women is different from those of the low risk group.
Detailed description
The researchers would like to investigate and compare the chemical composition in the normal breast between high risk women and general population.
Interventions
proton magnetic resonance spectroscopy was performed for the normal breast to evaluate the chemical composition of breast
Sponsors
National Taiwan University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
25 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Women without breast symptoms (without family history of breast cancer; or with at least first-degree relative of breast cancer) with negative mammography and ultrasound result in recent 3 months or contralateral normal breasts from women with newly diagnosed unilateral breast cancer * 25-75 years old.
Exclusion criteria
* renal function impairment * past history of anaphylactoid reaction to MRI contrast media (Gd-DTPA) * pregnant or lactating women * medication of HRT or oral pills in recent 6 months * past history of surgery of the breast (either side) * past history of breast cancer * with breast implant or silicone injection * past history of cardiac surgery, mechanical valve replacement, aneurismal clip, endotracheal tube or tracheostomy tube, any metallic implants.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| comparison of lipid water composition and ratio of the normal breasts in women of high risk group and low risk group. | up to 5 years ( July 2008 to June 2013) | This is a cross sectional study. And we just assess the chemical composition of normal breasts of women at a given time point, since the participants only received one time of study. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| to investigate the association between breast density and lipid water ratio of normal breasts | up to 5 years (July 2008 to June 2013) | to investigate whether there is association of breast density and chemical composition of normal breast on proton magnetic resonance spectroscopy. |
| to investigate the association between menopausal status and lipid water ratio of normal breasts | up to 5 years ( July 2008 to June 2013) | to investigate whether there is association of menopausal status and chemical composition of normal breast on proton magnetic resonance spectroscopy. |
Countries
Taiwan
Outcome results
None listed