Effect of Daily Music Listening on Stroke Recovery

Effect of Cognitive Stimulation on Recovery After Stroke

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01749709

Acronym

MUKU2

Enrollment

Registered

2012-12-17

Start date

2012-12-31

Completion date

2016-04-05

Last updated

2022-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Keywords

Stroke, Recovery, Music

Brief summary

Single blind randomized clinical trial including 50 stroke patients to investigate the effect of daily music listening on behavioral, neural and physiological recovery. Patients are randomized (1:1:1) to listen instrumental or vocal music, or audiobooks (recorded book reading) (control). Outcome measures are change in neuropsychological tests, change in self-reported mood, structural and functional magnetic resonance imaging changes and hormonal changes performed at acute, 3-month and 6-month stages.

Detailed description

Please see above

Interventions

BEHAVIORALAudiobook listening

BEHAVIORALMusic listening

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

TREATMENT

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Acute Hemispheral stroke

Exclusion criteria

* Previous neurological or current psychiatric disease, * severe aphasia

Design outcomes

Primary

Measure	Time frame	Description
Change in neuropsychological performance (verbal memory)	From acute to 3-month-stage	Verbal memory summary score (Rivermead Behavioral Memory Test (RBMT) story recall, auditory-verbal learning task)

Secondary

Measure	Time frame	Description
Change in mood	From acute to 3-month-stage	Profile of Mood States
Change in structural gray matter	From acute to 3-month-stage	Voxel-based morphometry
Change in structural gray matter changes	From acute to 6-month-stage	Voxel-based morphometry
Change in neuropsychological performance (Language skill)	From acute to 3-month-stage	Verbal fluency task
Change in neuronal function	From acute to 3-month stage	Resting state/task-based fMRI
Change in physiological stress level	From acute to 3-month-stage	Cortisol serum concentration
Change in structural white matter	From acute to 3-month stage	Diffusion-weighted imaging

Countries

Finland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 18, 2026