Pelvic Organ Prolapse
Conditions
Keywords
Pelvic organ prolapse, Connective tissue, Elastin, Collagen
Brief summary
The aim of our study is to investigate the alterations in connective tissue of vaginal wall in patients with and without pelvic organ prolapse (POP).
Detailed description
The tissue samples were taken from the anterior wall of vagina in the midline close to cervix or apex. The tissue samples were collected from the vaginal wall of the patients with pelvic organ prolapse (n=39) during vaginal prolapse surgery. Control samples (n=39) were taken from patients after vaginal or laparoscopic removal of the uterus. The formalin-fixed and paraffin embedded tissue samples were stained with Verhoeff van Gieson and Movat's pentachrome. Samples were examined by pathologist and gynecologist blinded as to the other investigator and to the pelvic organ prolapse status. In case of discrepancy investigators evaluated the samples together to gain consensus.
Interventions
None listed
Sponsors
Turku University Hospital
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* surgery for pelvic organ prolapse * hysterectomy due to other benign reasons than pelvic organ prolapse
Exclusion criteria
* surgery due to malignancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The elastin content in tissue samples in patients with or without pelvic organ prolapse. | september 2012 |
Secondary
| Measure | Time frame |
|---|---|
| The collagen content in tissue samples in women with or without pelvic organ prolapse. | September 2012 |
Countries
Finland
Outcome results
None listed