Emergencies
Conditions
Keywords
propofol, midazolam, duration of recovery, emergency procedure
Brief summary
Sixty patients who refer to the emergency ward and need any painful procedure in the ward are randomized into 2 groups. One group is sedated before the procedure using propofol-fentanyl and the other with midazolam-fentanyl, with the same depth of sedation. The two groups will be compared regarding recovery time and other parameters described below.
Interventions
DRUGPropofol
Propofol 1 mg/kg bolus then 500 microg/kg every 2 minutes until sedation level equivalent to Ramsey 3
DRUGMidazolam
Midazolam 0.03 mg/Kg stat and then the same dose repeated every 2 minutes until a sedation level of Ramsey 3 is achieved.
DRUGFentanyl
Fentanyl 2 microg/kg intravenous stat and every 2 minutes until the end of procedure
Sponsors
Tehran University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* age more than 18 * candidate for a painful procedure * negative past history of a serious medical condition * ASA score 0 and 1
Exclusion criteria
* deep sedation making the patient unable to answer the questions * pregnancy * allergy to drugs * hemodynamic instability * failure to consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Recovery time | Within one hour after sedation | Length of time before complete recovery from sedation is achieved |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Patients' Pain perception | Within one hour after sedation | Pain perception as measured by verbal numeric rating scale |
Other
| Measure | Time frame |
|---|---|
| Blood pressure | Within one hour after sedation |
| Oxygen saturation | Within one hour after sedation |
Countries
Iran
Contacts
Primary ContactMohammad Jalili, MD
Outcome results
None listed