Lung Cancer
Conditions
Keywords
Pulmonary function, Maximal oxygen uptake, Cardiorespiratory fitness, High-intensity training, Surgery
Brief summary
The purpose of the study is to investigate the change in pulmonary function and exercise capacity in lung cancer patients after pulmonary resection. Furthermore, to study the effect of training on aerobic capacity, muscular strength, morbidity and survival. Physical activity level by accelerometers, body composition by DXA and quality of life will also be reported.
Detailed description
Five year after surgery, all included patients will be reinvited to undergo a fourth health excame to study the long-term effects of exercise training on physical fitness, morbidity and survival.
Interventions
OTHERPhysical training
Physical training three times a week for 20 week including endurance and strength training compare to the as usual group as controls
OTHERAs usual
Controls, not training
Sponsors
Norwegian School of Sport Sciences
University Hospital, Akershus
Vestre Viken Hospital Trust
Oslo University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
30 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
* Non smal cell lung cancer * Patient living in Oslo or Akershus county and accepted for lung cancer surgery at Oslo University hospital and Akershus University hospital * were able to read and speak Norwegian
Exclusion criteria
* Mental incompetence or physical disability that makes it difficult to walk on a treadmill * Treatment or medical complications affecting ability to participate in an exercise group * \> 79 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Maximal oxygen uptake (VO2max) from baseline | An expected average of two weeks before surgery (baseline), four to six weeks after surgery, after six months and after 5 years | Change in VO2max from before to after surgery to measure the effect of surgery, and after six months to measure the effect of high-intensity training intervention, and after five years to study long-term effects |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Pulmonary function from baseline | Pulmonary function is measured three times; an expected average of two weeks before surgery, four to six weeks after surgery, after after six months and after five years. | Change in pulmonary function from before to after surgery and after the intervention |
Other
| Measure | Time frame | Description |
|---|---|---|
| DXA scan | An expected average of two weeks before surgery, four to six weeks after surgery, after six months and after five years | Change in body composition from before to after surgery and after the intervention |
| Quality of life | Measured three times: An expected average of two weeks before surgery, four to six weeks after surgery, after six months and after five years | Change in quality of life from before to after surgery and after the intervention |
| Physical activity | Measured three times: six weeks after surgery, after six months and after five years | Physical activity will be objectively measured by accelerometers for seven consecutive days to determine change in activity level after surgery |
Countries
Norway
Outcome results
None listed