Chronic Arsenic Poisoning
Conditions
Keywords
Arsenic, Arsenicosis, Garlic oil, Keratosis
Brief summary
Twenty patients of mild to moderate degree of arsenical palmer keratosis will be treated with garlic oil capsule orally for 12 weeks to examine its effectiveness in reducing body arsenic load and clinical symptoms. Similar treatment with similar number of arsenic exposed controls and healthy volunteers will be included for comparison.
Detailed description
Thousands of Bangladeshi are suffering from arsenic-induced keratosis affecting palms and soles. Palmer keratosis, particularly in young female, affects the socioeconomic condition. Till today there is no effective treatment. Twenty patients of mild to moderate degree of arsenical palmer keratosis will be treated with garlic oil in soft capsule (10 mg/day) orally for 12 weeks. Similar treatment will be given to 20 arsenic exposed controls and 20 healthy volunteers for comparison. The aim of this study is to examine the effectiveness of oral administration of garlic oil to reduce body arsenic load and clinical symptoms of arsenical palmer keratosis.
Interventions
DIETARY_SUPPLEMENTGarlic oil
Oral administration
Sponsors
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
(Patients): * history of taking arsenic contaminated water (\>50 ppb) for more than 6 months * patients having mild to moderate arsenical keratosis present on palm of the hand * patients those voluntarily agree to participate Inclusion Criteria (Arsenic exposed controls): * family member of the patient * drinking arsenic contaminated water from the same source as patient * those voluntarily agree to participate * no sign/symptom of palmer keratosis Inclusion Criteria (Healthy volunteers): * drinking arsenic safe water (\<50 ppb) * those voluntarily agree to participate
Exclusion criteria
* pregnancy * lactating mother * patient receiving treatment of arsenicosis * any other chronic disease like tuberculosis, diabetes mellitus, bronchial asthma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in the clinical symptom of keratosis in palm | 0 week (baseline) to 12 weeks (end) |
Secondary
| Measure | Time frame |
|---|---|
| Change in biochemical parameters (blood sugar, cholesterol and transaminase) after treatment | 0 week (baseline), 12 weeks (end) |
| Adverse effects following treament | 0 week (baseline), 12 weeks (end) |
| Change in the amount of arsenic in nail | 0 week (baseline), 20 weeks (end) |
Countries
Bangladesh
Outcome results
None listed