Chronic Cardiorespiratory Disease, Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension
Conditions
Brief summary
In a randomized, sham-controlled trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with pulmonary arterial or chronic thromboembolic pulmonary hypertension.
Interventions
PROCEDURESupplemental oxygen via a mask
Sponsors
University of Zurich
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* diagnosis of pulmonary arterial hypertension class I and IV (according to the latest WHO classification scheme of Dana Point 2008) * on optimized medical therapy and in stable condition for at least 4 week * desaturate in the 6 minute walking test by at least 4% to values \<92%
Exclusion criteria
* unstable conditions * pregnant women * patients with pulmonary venous hypertension * patients with relevant concomitant lung disease and severe daytime hypoxemia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Watt | 1 day |
| exercise time | 1 day |
Secondary
| Measure | Time frame |
|---|---|
| ventilatory equivalent of carbon dioxide (VE/VCO2) slope | 1 day |
| Peak oxygen uptake | 1 day |
| Changes in arterial blood parameters | 1 day |
| end-tidal pressures of carbon dioxide (PET CO2) | 1 day |
| Respiratory exchange ratio | 1 day |
Countries
Switzerland
Outcome results
None listed