Physiopathological Study of Autonomic Failure in Parkinson's Disease

Physiopathological Study of Autonomic Failure in Parkinson's Disease : a Monocentric Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01748409

Acronym

SYNAPark

Enrollment

Registered

2012-12-12

Start date

2013-02-28

Completion date

2016-03-31

Last updated

2016-10-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's Disease

Keywords

Autonomic failure, Parkinson's disease, electrophysiological assessment, neuropathological assessment

Brief summary

The aim of the study is to evaluate the autonomic failure in Parkinson's disease by clinical, electrophysiological and neuropathological examination.

Interventions

OTHERBiopsies of peripheral autonomic nervous system

OTHERAutonomic dysfunction questionnaires

OTHERElectrophysiological tests

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

45 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Patients with Parkinson's disease * ages 45 to 80 years, both genders * patients who signed informed consent

Exclusion criteria

* autonomic function modifying treatment * pre-existing neuropathy or risk factors for neuropathy * dementia * colonic disorders * coagulation disorders (may be due to treatment)

Design outcomes

Primary

Measure	Time frame	Description
Evaluate association between clinical autonomic failure and neuropathological autonomic failure on biopsies.	3 months	the main objective is to look after associations between : * anatomopathological signs of autonomic nervous system disorders seen on biopsies AND * clinical signs of signs of autonomic nervous system disorders seen through functional tests or through symptoms indicated by the patient on questionaries.

Secondary

Measure	Time frame	Description
Evaluate association between autonomic failure and severity factors in Parkinson's disease	3 months	Autonomic failure will be assessed through questionaries on symptoms and through functional tests. Severity factors in parkinson disease will refer to various parameters like patient age.
Evaluate consequences of autonomic failure on quality of life and sleep quality	3 months	quality of life and of sleep will be assessed through functional tests and through questionaries.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 7, 2026