Insulin Resistance, Obesity
Conditions
Keywords
Obesity, insulin resistance, muscle perfusion
Brief summary
In the present study, muscle perfusion will be studied before and after an oral glucose challenge following a fasting period.
Detailed description
Based on data from previous studies, this physiological response is blunted in obese subjects, and the investigators expect these responses to be restored when the glucose load is combined with tea or beetroot juice in obese, insulin resistant men.
Interventions
Sponsors
Radboud University Medical Center
Unilever R&D
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
30 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Male sex * Aged 30-70 years. * Obesity (BMI\>30 kg/m2) * insulin resistance as fasting glucose levels \>6.1 mmol/L. * Reported intense sport activities \>10 h/w. * Reported alcohol consumption \>28 units/w * Signed Informed consent * Currently not smoking and being a non-smoker for at least 3 months prior to the start of the study.
Exclusion criteria
* BMI ≥ 40 kg/m2. * Presence of cardiovascular disease. * Presence of sudden cardiac death in a 1st degree relative at an age \<50 years. * Presence of diabetes mellitus type 2. * Regular tea drinker (\> 2 cups per day)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vascular resistance | Average of values obtained at 30, 60, 90, 120, 150 and 180 minutes after test product intake corrected for the value obtained at approximately 20 minutes before test product intake (baseline) | Vascular resistance (arm and leg) as obtained from venous occlusion plethysmography and corrected for blood pressure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| echo-Doppler | Approximately 20 minutes before (baseline) and 30, 60, 90, 120, 150 and 180 minutes after test product intake | Postprandial muscle blood flow (arm and leg) measured by echo-Doppler at the brachial artery and the superficial femoral artery |
| Near-infrared spectroscopy | Approximately 20 minutes before (baseline) and 30, 60, 90, 120, 150 and 180 minutes after test product intake | Postprandial muscle blood flow (arm) measured by near-infrared spectroscopy on the extensor carpi radialis brevis muscles of the forearm |
| Glucose and insulin | Approximately 20 minutes before (baseline) and 30, 60, 90, 120, 150 and 180 minutes after test product intake | Glucose and insulin in venous blood plasma |
| Vascular resistance exploratory | Approximately 20 minutes before (baseline) and 30, 60, 90, 120, 150 and 180 minutes after test product intake | Vascular resistance (arm and leg) as obtained from venous occlusion plethysmography and corrected for blood pressure as an exploratory parameter. |
Countries
Netherlands
Outcome results
None listed