Sarcoidosis
Conditions
Keywords
Sarcoidosis, Cardiac Magnetic Resonance
Brief summary
The primary objective of this study was to determine the ability of cardiac magnetic resonance (CMR) to identify cardiac involvement in patients with sarcoidosis. Patients were to undergo CMR in addition to routine clinical evaluation.
Detailed description
In patients with sarcoidosis, cardiac death is a leading cause of mortality which may represent unrecognized cardiac involvement. Cardiovascular magnetic resonance (CMR) can detect cardiac involvement including minute amounts of myocardial damage. Therefore, the objective of this study was to determine the usefulness of CMR and compare it with standard clinical evaluation for cardiac involvement. Patients with documented extracardiac sarcoidosis or clinically suspected cardiac sarcoidosis will be enrolled.
Interventions
None listed
Sponsors
Duke University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Biopsy proven sarcoidosis * Suspected cardiac sarcoidosis
Exclusion criteria
* Contraindication to MRI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cardiac mortality | > 1year | — |
| arrhythmic death | > 1year | — |
| Pulmonary mortality | > 1year | only in subset of patients with pulmonary sarcoidosis |
Secondary
| Measure | Time frame |
|---|---|
| Cardiac Transplant | > 1 year |
| all-cause mortality | > 1year |
| PPM placement/high grade AV block | > 1 year |
| arrhythmic events | > 1year |
| Pulmonary Transplant | > 1 year |
Countries
United States
Contacts
Primary ContactHan W Kim, MD
Backup ContactRaymond J. Kim, MD
Outcome results
None listed