Postmenopausal Disorder
Conditions
Keywords
Postmenopausal Women, Body Composition, Metabolic Syndrome, Menopause Symptoms
Brief summary
The purpose of this study is to investigate anthropometric, metabolic, cardiovascular and symptomatic profiles in postmenopausal women.
Detailed description
When aging, the body composition changes, leading to a reduction of muscle mass and strength, and to an increase in total body fat. These body composition changes have especially been observed in postmenopausal women, due to the hormonal changes taking place. After the menopause, the gynoid fat distribution with fat deposits in the gluteo-femoral region changes to an android fat distribution with an increased upper body fat, especially in the abdominal region. These consequences of the menopause associated with a decrease in aerobic capacity and reduced total energy expenditure may lead to the metabolic syndrome (MetS). The aim of this study was to investigate the anthropometric, metabolic, cardiovascular and symptomatic profile in gynoid and android postmenopausal women.
Interventions
OTHERClinical exams
Physiological and biochemical tests; quality of life questionnaire; body composition measurement
Sponsors
Fundação de Amparo à Pesquisa do Estado de São Paulo
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
University of Sao Paulo
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
50 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Postmenopausal women * Caucasian * 50-60 years of age
Exclusion criteria
* Neurological disease * Pulmonary disease * Cardiac disease * Oncological disease * Musculotendinous or articular injuries * Hormone replacement therapy * Cigarette smoking
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Relationships between postmenopause and fat distribution | Baseline | Anthropometric measurements: waist-to-hip ratio and body mass index |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of aerobic capacity between android and gynoid postmenopausal women | Baseline | Progressive aerobic testing on treadmill (Modified Bruce Protocol): estimated maximum oxygen consumption; metabolic equivalents; blood pressure; heart rate |
| Comparison of metabolic parameters between android and gynoid postmenopausal women | Baseline | Biochemical tests: the serum level of estradiol, urea, creatinine, triglycerides, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein (VLDL) cholesterol, insulin and glucose |
| Comparison of quality of life between android and gynoid postmenopausal women | Baseline | Menopause Rating Scale (MRS): somatic symptoms; psychological symptoms; urogenital-sexual problems |
| Comparison of the body composition between android and gynoid postmenopausal women | Baseline | Body composition: bipolar electrical bioimpedance (body fat and lean mass) and skinfolds (triceps, subscapular, suprailiac, abdominal, anterior thigh, medial calf) |
Countries
Brazil
Outcome results
None listed