Seizure
Conditions
Keywords
Seizure, Acid-suppressing drugs, Epidemiology
Brief summary
The purpose of this study is 1. to estimate the incidence of seizure in the general population and stratified by epilepsy status 2. To estimate the relative risk of seizure associated with use of proton pump inhibitors and histamine 2 receptor antagonist and stratified by epilepsy status
Detailed description
A cohort study with a nested case control analysis on the association between acid-suppressing drugs and seizures using THIN database in the UK
Interventions
DRUGRisk of seizure
Patients newly prescribed PPI and H2RA, respectively
Sponsors
AstraZeneca
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Primary care physician for at least 2 years. * Computerized prescription history of at least 1 year. * Patients will have to be free of acid-suppressing drugs (PPI or H2RA) for at least one year. * No diagnosis of cancer. * No alcohol abuse or alcohol-related disease- No drug abuse.
Exclusion criteria
* Patients with at least 1 prescription of PPI or H2RA in the year prior to start date. * Cancer before start date. * Alcohol abuse or alcohol-related disease before start date. * Drug abuse before start date.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of seizure in the general population and stratified by epilepsy status. | Participants will be followed for the duration of the study period 1 January 2005-31 December 2011, an expected average of 3 years. |
| Follow-up of safety outcomes: First recorded entry of seizure. | Participants will be followed for the duration of the study period 1 January 2005-31 December 2011, an expected average of 3 years. |
Countries
Spain
Outcome results
None listed