Microsphere Localization Using PET/MRI or PET/CT in Patients Following Radioembolization

Pilot Study of Microsphere Localization Using PET/MRI or PET/CT in Patients Following Radioembolization

Status

Terminated

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01744054

Enrollment

Registered

2012-12-06

Start date

2012-10-25

Completion date

2017-04-03

Last updated

2018-03-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Neoplasms

Brief summary

The successful localization of the y90 microspheres by PET/MR and/or PET/CT scans would be a useful tool in individualizing patient care after the radioembolization procedure. The information from a PET/MR or PET/CT scan would allow for early evaluation of the technical success of the procedure.

Interventions

DEVICEPET/MR

DEVICEPET/CT

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Participant must successfully complete the MRI screening form if receiving an MRI * Participant must be scheduled to undergo radioembolization for any indication * Participant must be ≥ 18 years of age * Participant must be able to understand and willing to sign an Institutional Review Board (IRB)-approved written informed consent document

Exclusion criteria

* Participant must not have any contraindications to MRI scanning * Patient must not be pregnant or breastfeeding * If agreeing to MRI contrast, participant must not have renal insufficiency (glomerular filtration rate (GFR \< 30 mL/min/1.73 m2) measured within the past 60 days * If agreeing to MRI contrast, participant must not be on dialysis * If agreeing to MRI contrast, participant must not have had a prior allergic reaction to gadolinium-based contrast agents * PET/MRI or PET/CT is not able to be scheduled within 72 hours of radioembolization

Design outcomes

Primary

Measure	Time frame	Description
Evaluate y90-PET/MRI and PET/CT for potential on reporting technical success of radioembolization	1 day (one time event for patient)	A diagnostic radiologist and a nuclear medicine physician will evaluate the images and will determine whether technical success of the procedure can be determined. They will rate the images if they are 'adequate' to report on these two measures.
Evaluate y90-PET/MRI and PET/CT for potential on reporting presence of extrahepatic deposition of microspheres	1 day (one time event for patient)	A diagnostic radiologist and a nuclear medicine physician will evaluate the images and will determine any presence of extrahepatic deposition of microspheres.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026