Genetic and Neural Predictors of Adolescent Depression

Towards Identification of Genetic and Neural Predictors of Adolescent Depression

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01743716

Enrollment

100

Registered

2012-12-06

Start date

2013-04-01

Completion date

2021-12-01

Last updated

2026-03-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depressive Disorder

Keywords

Major Depressive Disorder, MDD, depression, adolescent

Brief summary

This study aims to examine the relationship between mood and brain activity in adolescent girls in order to better understand the genetic and neural predictors of adolescent depression. The participants in this study will be healthy female adolescents aged 12-14 and their mothers. They will participate for a total of six months. Adolescent participants will have three study sessions at McLean Hospital, and during two of them, their mothers will also have assessments. Adolescent assessments will include interviews, questionnaires, computer tasks, and collection of a saliva sample for genetic analyses. Their second study visit will include an fMRI scan. Parent assessments will include an interview, questionnaires, and a computer task.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Age

12 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Adult Cohort A. MDD Mothers Cohort Inclusion Criteria: * Current or past Major Depressive Disorder * English as first language or English fluency * Biological daughter who meets inclusion/

Exclusion criteria

for High Risk Female Adolescent B. Healthy Control Mothers Cohort Inclusion Criteria: * No history of psychopathology * English as first language or English fluency * Biological daughter who meets inclusion/

Design outcomes

Primary

Measure	Time frame
Neurobiological Activity in Frontostriatal and Mesolimbic Regions	Baseline
Depressive Symptoms	6 months

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORRandy P. Auerbach, PhD

Mclean Hospital

PRINCIPAL_INVESTIGATORDiego A. Pizzagalli, PhD