Postoperative Pain and Postoperative Morphine Consumption After Abdominal Hysterectomy
Conditions
Brief summary
A Prospective double-blinded randomized clinical trial to test the effect of transversus abdominis plane block on postoperative pain and opoid consumption after abdominal hysterectomy. Two groups of each 24 patients. All patients are given general anesthesia. The patients are randomized to have a ultrasound guided bilateral transversus abdominis plane block with either 2 x 20 ml 0,75 % ropivacaine or 2 x 20 ml of 0,9 saline. All patients are provided with a PCA for self administration of morphine. Pain score on visual analog scale, nausea and vomiting are monitored at 1, 2, 4, 6, 8 and 24 hours postoperatively as well as the total consumption of morphine after 24 hours.
Interventions
PROCEDURETAP Block Ropivacaine 0,75 %
PROCEDURETAP Block Saline 0,9 %
Sponsors
Hvidovre University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Assigned to elective abdominal hysterectomy * Must be able to understand and speak danish * Must be able to give verbal and written consent
Exclusion criteria
* Abuse of alcohol or medicin * Daily treatment with opoids or glucocorticoids * Allergy towards any kind of localanesthetic drug * Intolerance toward morphine * Psychiatric desease * Age below 18
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total morphine consumption during first 24 hours postoperatively | At 24 hours postoperatively |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative pain by visual analog scale at | Monitored at 1, 2, 4, 6, 8 and 24 hours postoperatively | Monitored at 1, 2, 4, 6, 8 and 24 hours postoperatively by one of the investigators at rest, when coughing and when walking |
Other
| Measure | Time frame | Description |
|---|---|---|
| Postoperative nausea and vomiting | Monitored at 1, 2, 4, 6, 8 and 24 hours postoperatively | Monitored at 1, 2, 4, 6, 8 and 24 hours postoperatively by one of the investigators |
| Length of stay | First 72 hours after surgery | Length of hospital stay counted in days |
| Time until mobilization | First 24 hours postoperatively | First mobilization defined as walking on the floor |
Countries
Denmark
Outcome results
None listed