Contrast Induced Acute Kidney Injury
Conditions
Keywords
Contrast-induced nephropathy, Contrast media, Angiography, Coronary percutaneous intervention
Brief summary
The purpose of this study is to determine whether hydration with sodium bicarbonate is more effective than hydration with sodium chloride to prevent contrast nephropathy in patients undergoing primary coronary intervention for acute ST elevation myocardial infarction.
Interventions
DRUGIsotonic saline
Sponsors
Ospedale Misericordia e Dolce
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Consecutive patients with AMI candidates for primary PCI presenting within 12 h of symptom onset with ST-segment elevation of more 1 mm in at least two contiguous leads of electrocardiogram.
Exclusion criteria
* contrast medium administration within the 10 days * end-stage renal failure requiring dialysis * refusal to give informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of contrast-induced acute kidney injury | 2 days | contrast-induced acute kidney injury is defined as an increase in serum creatinine \>= 0.3 mg/dL over the baseline value within 2 days after the administration of the contrast medium |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| adverse clinical events | 1 month | adverse clinical events within 1 month including in-hospital death and need for dialysis or hemofiltration |
Countries
Italy
Outcome results
None listed