Effects of Physical Activity on the Brain in Parkinson's Disease (PD)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01741584

Enrollment

Registered

2012-12-05

Start date

2010-12-31

Completion date

Unknown

Last updated

2016-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's Disease

Brief summary

The aim of the study is to investigate whether exercise improves cognitive and motor functions in Parkinson's disease. To test this hypothesis, the researchers study general brain functions in subjects with PD during a 6-months exercise program.

Interventions

BEHAVIORALstationary bike exercise

BEHAVIORALaerobic

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

35 Years to 80 Years

Healthy volunteers

Inclusion criteria

* UPDRS \<15 * L-DOPA responsive * \<5 yrs since diagnosis

Exclusion criteria

* severe other diseases * MMSE \< 26 * treatment with psychiatric medication

Design outcomes

Primary

Measure	Time frame
UPDRS motor score	Prior to intervention and after 6 months of intervention

Secondary

Measure	Time frame
Functional/Structural brain changes	Prior to intervention and after 6 months of intervention
Plasma biomarkers	Prior to intervention and after 6 months of intervention
Cognitive Function based on neuropsychological test-performance	Prior to intervention and after 6 months of intervention

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026