Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance Imaging

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01741246

Enrollment

Registered

2012-12-04

Start date

2011-09-30

Completion date

2015-06-30

Last updated

2015-06-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Migraine, Migraine

Keywords

Episodic migraine, Chronic migraine, Magnetic resonance imaging, Positron emission tomography

Brief summary

Investigators hypothesize that chronic primary headaches are accompanied by a discrete pattern of brain metabolism and activity involving brain structures related to the development of acute exacerbations as well as pain modulation. Such structures include the brainstem, hypothalamus, and orbitofrontal cortex and can be defined using functional brain imaging.

Detailed description

Specific aims of the study include: 1. To determine the pattern of brain metabolism using positron emission tomography (PET) found in chronic migraine, episodic migraine and control patients. 2. To determine changes of resting state brain networks using magnetic resonance imaging (MRI) between patients with chronic or episodic headache and healthy volunteers.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Patients aged 18-65 * No medical contraindication. Chronic headache group: * Patients with chronic primary headaches who are experiencing phases with background pain as well as habitual pain exacerbations. * Able to provide informed consent. * Not pregnant or planning to become so, with a pregnancy test prior to scanning. Control group and Episodic migraine group: * Patients with episodic migraine * Able to provide informed consent. * Not pregnant or planning to become so, with a pregnancy test prior to scanning.

Exclusion criteria

* Taking a migraine preventive currently or in the last fifteen days. * Known claustrophobia * Patient is pregnant, planning to be pregnant, or becomes pregnant. * Patients with metal implants. * Patients who have had a study involving radiation within the one year prior to enrolling in this study

Design outcomes

Primary

Measure	Time frame	Description
Pattern of brain metabolism using positron emission tomography(PET).	Estimated to be approximately three years post baseline	Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance Imaging to determine the pattern of brain metabolism.
Changes of resting state brain networks using magnetic resonance imaging (MRI)	Estimated to be approximately three years post baseline	Neuroimaging Studies of Chronic Primary Headaches Using Positron Emission Tomography and Magnetic Resonance Imaging (MRI) To determine any changes of resting state brain networks

Countries

United States

Outcome results