Noninvasive Ventilation for Respiratory Distress Syndrome
Conditions
Keywords
Nasal CPAP, Nasal IMV, Surfactant, Preterm infants
Brief summary
The investigators aimed to compare the efficacy of nasal intermittent mandatory ventilation (IMV) and nasal continuous positive airway pressure (CPAP) in early rescue surfactant treatment in preterm infants.
Interventions
DEVICENasal CPAP (SLE)
PEEP: 4-6 cmH2O, Flow: 8 to 10 L/minute
DEVICENasal IMV (SLE)
PIP: 15-20 cmH2O, PEEP: 4-6 cmH2O, Inspiratory time: 0.4-0.5 second, Rate: 20-30 /minute
Sponsors
Mehmet Yekta
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 2 Hours
Healthy volunteers
No
Inclusion criteria
\- Gestational age 26-32 weeks The criteria for failure were met by at least 1 of the following: * pH: 7.10 and PaCO2: 70 mm Hg * Recurrent apnea with \>3 episodes (Prophylactic caffeine were used in all infants) * Single episode of apnea that required bag-and-mask ventilation * PaO2: 50 mmHg with a fraction of inspired oxygen of \>0.5.
Exclusion criteria
* Major congenital anomalies * Presence of cardiovascular instability * Intubation at admission to the NICU * Consent not provided or refused
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Efficacy of nasal intermittent mandatory ventilation (IMV) and nasal continuous positive airway pressure (CPAP) in early rescue surfactant treatment in preterm infants | 3 months | If infants needed invasive MV or Required a fraction of inspired oxygen of \>40% to maintain the targeted saturation of \>88% to 92%, surfactant treatment will give for respiratory distress syndrome (RDS). It means that nasal IMV or CPAP is ineffective. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Complications of respiratory support | 3 months | respiratory insufficiency, pneumothorax |
Countries
Turkey (Türkiye)
Outcome results
None listed