Comparison of Low-volume PEG Plus Ascorbic Acid Versus Standard PEG Solution as Bowel Cleansing for Colonoscopy

Randomized Controlled Trial of Low-volume PEG Plus Ascorbic Acid Versus Standard PEG Solution as Bowel Cleansing for Colonoscopy

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01740518

Enrollment

360

Registered

2012-12-04

Start date

2012-03-31

Completion date

Unknown

Last updated

2012-12-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colonoscopy [E01.370.372.250.250.200]

Brief summary

The purpose of this study is to compare two regimens of low volume (2L) polyethylene glycol(PEG)plus ascorbic acid versus standard volume (4L) PEG alone for bowel preparation in out-patients

Detailed description

Inadequate bowel preparation may lead to a longer colonoscopy, and to an inability to identify lesions. PEG can provide a rapid orthograde peroral approach to colonic lavage without producing significant fluid or electrolyte changes. Thus PEG is now commonly used for bowel preparation. However, large amounts and unsatisfactory taste of PEG solution are generally poorly tolerated. a new low volume PEG-based bowel cleansing agents became available at foreign countries. Although several studies reported the efficacy and improved compliance of these low volume PEG plus ascorbic acid solution for colonoscopy, but result in Korean patients was not-recognized.

Interventions

DRUGpolyethylene glycol, ascorbic acid

comparison of different solutions for bowel preparation

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

19 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Out-patients for colonoscopy

Exclusion criteria

* age under 19 years or over 80 years * Intestinal obstruction * Women of pregnant, breastfeeding, or at risk of becoming pregnant * major psychiatric illness * known allergy to PEG * serious condition- severe cardiac, renal, or metabolic diseases * past history of colon resection * current acute exacerbation of chronic inflammatory bowel disease * functional constipation defined by Rome III diagnostic criteria

Design outcomes

Primary

Measure	Time frame	Description
The efficacy of bowel preparation	one day (after colonoscopy)	three segmental preparation scoring (0\ 4, Rt., mid, Lt.colon) total preparation grade:A,B,C,D (A or B was defined successful bowel cleansing) Influence of the intake of additional fluid in PEG+ascorbic acid

Secondary

Measure	Time frame	Description
Patient's compliance and acceptability	one day (after injestion of preparation solution)	satisfaction (Visual Analogue Scale) amount of ingestion, frequency and amount of vomiting, tolerability, complication, taste

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026