Clinical Value of Remote Ischemic Preconditioning

Does Remote Ischemic Preconditioning Reduce the Incidence of Postoperative Atrial Fibrillation in Patient Undergoing Coronary Artery Bypass Graft Surgery?

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01740102

Enrollment

Registered

2012-12-04

Start date

2012-08-31

Completion date

2013-09-30

Last updated

2016-08-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation, Heart Diseases

Keywords

Ischemic preconditioning, Coronary artery bypass, Preoperative care, Postoperative period

Brief summary

Objectives: Despite utilization of available means for cardioprotection during cardiac surgery, myocardial injury still occurs. Further improvement of cardioprotection is therefore necessary. Remote ischemic preconditioning (RIPC) is an easy and non-invasive method. Laboratory research has shown promising results regarding myocardial survival during open heart surgery, but the clinical value of RIPC is still largely unknown. The investigators hypothesize that RIPC before coronary artery bypass grafting (CABG) reduces the incidence of postoperative atrial fibrillation (POAF).

Interventions

PROCEDURERIPC

The remote ischemic preconditioning will consist of three sequential sphygmomanometer cuff inflations. The cuff will be inflated up to 200 mmHg for 5 minutes and then deflated for 5 minutes. This cycle will be performed three times in total. The entire preconditioning will therefore last for 25 minutes.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Elective isolated on-pump CABG surgery * Informed consent

Exclusion criteria

* Patients with a severe pulmonary disease * Patients with renal failure (GFR\<30 mL/min/1.73 m2) * Patients with liver failure * Peripheral vascular disease affecting the upper limbs * Patients on sulfonylurea derivatives. * Patients with atrial fibrillation in their case history * Prior cardiac surgery (Re-operations)

Design outcomes

Primary

Measure	Time frame	Description
Postoperative atrial fibrillation	Up to 10 days after surgery	A patient will be classified as belonging to the postoperative atrial fibrillation group if they have any episode of atrial fibrillation, measured by telemetry, lasting more than 1 minute during their postoperative days at the hospital.

Secondary

Measure	Time frame
Length of hospital stay	Maximum 14 days

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026