Alcohol Consumption, Cerebral Blood Flow
Conditions
Keywords
Alcohol consumption, Kudzu extract, Cerebral blood flow
Brief summary
This study is designed to test whether treatment with kudzu extract will increase the rate at which alcohol enters the brain as measured by rapid proton magnetic resonance spectroscopy (1H-MRS).
Interventions
DIETARY_SUPPLEMENTKudzu extract
Sponsors
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Mclean Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
21 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Capable of understanding and complying with the protocol * Good physical and mental health (normal physical exam, ECG, blood and urine chemistries, no psychopathologies) * Body Mass Index between 18-30, inclusive * Age 21-40 years * Moderate alcohol drinkers (less than 20 drinks/week) * Have a stable living situation with current postal address * No contraindications to MR scanning (see MR scanning
Exclusion criteria
below)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate at which alcohol enters the brain | 2.5 hours after drug administration | To determine the effects of kudzu extract treatment on the rate at which alcohol enters the brain and to determine if this is due to a change in cerebral blood flow as measured by rapid proton magnetic resonance spectroscopy (1H-MRS). |
Secondary
| Measure | Time frame |
|---|---|
| Impact of alcohol and kudzu on resting state networks (RSN). | 2.5 hours after drug administration |
Outcome results
None listed