Colorectal Surgery
Conditions
Brief summary
Epidural anesthesia has been found to manipulate the hyperglycemic response to surgery. It is unclear, however, whether the preoperative metabolic status of the surgical patient plays a role in the degree of this hyperglycemic response. For instance, the presence of low insulin sensitivity before surgery could predispose the individual to an altered metabolic response after surgery. In this case, it would be appropriate to identify adequate interventions that attenuate the response to surgical stress and facilitate the recovery process. The aims of this research projects are the following: 1. To determine the extent in which epidural local anesthetics, initiated before surgery and continued after surgery, improves insulin secretion in patients with preoperative low insulin sensitivity. 2. To understand which measures of postoperative recovery are sensitive to the restoration of insulin secretion in this particular group of patients
Interventions
PROCEDUREAnesthesia
Patients will be randomized to receive either epidural or general anesthesia for pain management throughout their surgery.
Sponsors
Gabriele Baldini, MD, MSc, Assistant Professor
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients receiving elective resection of malignant, non metastatic, colorectal lesions
Exclusion criteria
* American Society of Anesthesiologists (ASA) health status class 4-5 * Dementia,neuromuscular disease, psychosis * Cardiac abnormalities * Severe end-organ disease such as cardiac failure (New York Heart Association classes I-IV) * Chronic obstructive pulmonary disease * Renal failure (creatinine \> 1.5 mg/dl) * Hepatic failure (liver transaminases \>50% over the normal range) * Diabetics with glycosylated hemoglobin \> 6% * Steroid consumption longer than 30 days sepsis * Morbid obesity (body mass index \>40) * Anemia (hematocrit \< 30 %, haemoglobin \<10g/dl, albumin \< 25mg/dl). * Patients will be excluded if they have poor English or French comprehension.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hyperinsulinemic-euglycemic clamp | up to 2 days after surgery | The Hyperinsulinemic-euglycemic clamp is the gold standard for measuring insulin sensitivity. Patients receive a 2 hour infusion of glucose and insulin, which is adjusted throughout the study period in order to maintain a blood glucose concentration at 5.5mmol/L. The test will take place one week before surgery and on the second postoperative day. |
Countries
Canada
Outcome results
None listed