Caries Dentalis
Conditions
Keywords
Probiotic bacteria, Caries dentalis, QLF
Brief summary
Clinical trials in children and adults have suggested that daily consumption of probiotic lactic acid bacteria can reduce caries risk and caries development in primary teeth in preschool and stop root caries in the elderly. However, it is not known whether probiotic bacteria can affect the increased porosity in young permanent teeth in children and adolescents with many cavities. It can be difficult to measure the increased porosity of the enamel by tooth decay, but this can be done using quantitative laser fluorescence (QLF). The method is based on visible light with a wavelength of 370 nm, addressing enamel. This produces an image consisting of red and green color tones and the dominant color of the enamel is green. Increased porosity of the enamel, resulting in a reduction of the auto-fluorescence and the loss (or gain) of the mineral can be quantified by means of a corresponding software. The purpose of this study is to investigate the effect of a daily supplement of probiotic lactic acid bacteria on the loss of mineral in enamel assessed with QLF. The null hypothesis is that the mineral content will not differ from baseline in either the test group or the placebo group.
Interventions
BIOLOGICALL. retueri
two tablets a day for 6 weeks
BIOLOGICALPlacebo
Sponsors
University of Copenhagen
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
12 Years to 17 Years
Healthy volunteers
Yes
Inclusion criteria
* two sites with white spot lesions in anterior teeth
Exclusion criteria
* antibiotic treatment within 2 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in enamel porosity | Baseine and 12 weeks | Change in enamel porosity assed by QLF |
Countries
Denmark
Outcome results
None listed