GLOBAL Clinical Study

Conditions

Coronary Artery Disease

Brief summary

The GLOBAL study is an international multi-center, prospective study designed to enroll up to 10,000 consecutive eligible subjects who are clinically referred for coronary CT angiography for assessment of suspected coronary artery disease (CAD). The purpose of the study is to perform extensive biomarker analysis of atherosclerosis in patients phenotyped using advanced imaging modalities of atherosclerosis.

Szilárd Vörös, Wess Boatwright, Bradley Brown, Tony Lozama, David Watson et al. (10 authors)

Circulation2025-11-03

10.1161/circ.152.suppl_3.4358445

Bayesian network analysis of panomic biological big data identifies the importance of triglyceride-rich LDL in atherosclerosis development

Szilárd Vörös, Aruna T. Bansal, Michael R. Barnes, Jagat Narula, Pál Maurovich‐Horvat et al. (22 authors)

Frontiers in Cardiovascular Medicine2023-01-045 citations

10.3389/fcvm.2022.960419

Heritability of Coronary Artery Disease: Insights From a Classical Twin Study

Zsofia D. Drobni, Marton Kolossvary, Julia Karady, Adam L. Jermendy, Adam D. Tarnoki et al. (13 authors)

Circulation Cardiovascular Imaging2022-03-0143 citations

10.1161/circimaging.121.013348

Standardised computed tomographic assessment of left atrial morphology and tissue thickness in humans

John Whitaker, Júlia Karády, Rashed Karim, Catalina Tobon‐Gomez, Thomas E. Fastl et al. (25 authors)

IJC Heart & Vasculature2020-12-2414 citations

10.1016/j.ijcha.2020.100694

Abstract 16589: First Demonstration That Small Lp(a) Particles, With Kringle IV Repeats of 24 or Less, but Not Large Lp(a) Particles (More Than 24 Kringle IV Repeats), Are Atherogenic

Gustavo Vazquez, Brad Brown, Idean Marvasty, Etienne Guillot, Phillip Janiak et al. (10 authors)

Circulation2018-11-06

10.1161/circ.138.suppl_1.16589

Comparison of Quantity of Coronary Atherosclerotic Plaques Detected by Computed Tomography Versus Angiography.

Kolossváry M, Szilveszter B, Édes IF, Nardai S, Voros V, Hartyánszky I, Merkely B, Voros S, Maurovich-Horvat P.

2016-04-0517 citations

10.1016/j.amjcard.2016.03.031

Precision phenotyping, panomics, and system-level bioinformatics to delineate complex biologies of atherosclerosis: rationale and design of the "Genetic Loci and the Burden of Atherosclerotic Lesions" study.

Voros S, Maurovich-Horvat P, Marvasty IB, Bansal AT, Barnes MR, Vazquez G, Murray SS, Voros V, Merkely B, Brown BO, Warnick GR.

2014-09-0614 citations

10.1016/j.jcct.2014.08.006

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

No

Inclusion criteria

1. Ages 18-90 2. Caucasian and of Non-Hispanic or Non-Latino origin 3. Referral for coronary CT angiography to evaluate for presence of CAD 4. The patient has signed the appropriate Institutional Review Board approved Informed Consent Form

Exclusion criteria

1. Immunosuppressive or immunomodulatory therapy including any dose of systemic corticosteroids in the preceding 30 days (except if steroids are administered as pre-medication prior to contrast administration for CT scan within 24 hours). 2. Chemotherapy in the preceding year 3. Major surgery in the preceding 2 months 4. Blood or blood product transfusion in the preceding 2 months 5. Subjects for whom coronary CT angiography is contraindicated per institutional standard of care 6. Subjects with previous coronary arterial revascularization (PCI or CABG) 7. Subjects with atrial fibrillation/flutter or frequent irregular or rapid heart rhythms, which occurred within the past 3 months 8. Subjects with a pacemaker or implantable cardioverter-defibrillator implant 9. Active congestive heart failure or the presence of known non-ischemic cardiomyopathy 10. Known genetic disorders of atherosclerosis, lipid or lipoprotein metabolism

Design outcomes

Primary

Measure	Time frame	Description
Genome-Wide Association	Baseline	The primary analysis will be a genome-wide association analysis, to determine candidate genes and markers underlying coronary artery disease.

Countries

Australia, Canada, Croatia, Germany, Hungary, Netherlands, Poland, United Kingdom, United States

Outcome results