Hip Fracture
Conditions
Keywords
hip fracture, risk factors, vitamin K1, vitamin D, bone turnover markers, osteocalcin, undercarboxylated osteocalcin, bone specific alkaline phosphatase (BALP), insulin like growth factor 1 (IGF1), parathyroid hormone (PTH)
Brief summary
Low Body Mass Index (BMI) is a risk factor for hip fracture, but it is unknown if it is the low BMI per se that increases risk of hip fracture or if specific micro-nutrients contribute. The investigators want to elucidate this aspect in a case control study studying micronutrients in serum and bone turnover markers of hip fracture patients compared with controls of the same age.
Interventions
None listed
Sponsors
University of Oslo
Oslo University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
Cases are admitted acutely for a femoral neck fracture, a trochanteric or a subtrochanteric femoral fracture.
Exclusion criteria
* Hip fracture as part of multi-trauma or high energy trauma (defined as a fall from a higher level than 1 metre). One recent fracture in addition to the hip fracture (e.g. radius or shoulder) is acceptable. * Regarded as moribund at admittance. * Absence of a valid informed consent or assent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| micronutrient association with increased risk of hip fracture | At admission | Blood was drawn for micronutrient analysis in hip fracture patients and in controls |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Are micronutrients related to bone turnover markers | At admission | Blood was drawn for bone turnover analysis. Correlation analysis with micronutrients was performed |
Countries
Norway
Outcome results
None listed