Dementia
Conditions
Keywords
High intensity aerobic training
Brief summary
Aging is associated with a loss of brain function and conditions such as dementia and Alzheimer's disease. It is likely that decreased brain metabolism is contributing to the progression of age related degenerative diseases. Aerobic exercise training can increase brain volumes and is associated with decreased risk for degenerative brain conditions. However, little is know about the changes that occur to brain metabolism with aerobic training and aging.
Interventions
BEHAVIORALHigh intensity aerobic training
High intensity aerobic interval training will be performed 12-weeks. Exercise training will last 1 hour per day, 5 days per week and include high intensity interval cycling at \ 70-95% maximum workload for 4 minutes followed by 3 minutes of rest.
BEHAVIORALSedentary Control
Sedentary control participants will not perform any regular exercise for 12-weeks.
Sponsors
Mayo Clinic
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
Healthy sedentary adults aged 18-30 or 65-80 years of all ethnicities will be eligible. Pregnant women, children, prisoners or other at risk populations will not be recruited. Inclusion Criteria: * Age 18-30 years or 65-80 years
Exclusion criteria
* Body mass index (BMI) \>31 kg/m2 * Smoking * Pregnancy * Participation in structured exercise (\>2 times per week for 30 minutes or longer) * Cardiovascular, metabolic (type 2 diabetes, fasting plasma glucose at or above 110 mg/dL and untreated hypo- or hyperthyroidism) or renal disease * Orthopedic problems that would keep them from being able to ride an exercise bicycle, lift weights or do a combination of these exercise * Medications that are known to impact on mitochondrial function: Corticosteroids, opiates, benzodiazepines, tricyclic antidepressants, beta blockers, sulfonylureas, insulin, anticoagulants, barbiturates, insulin sensitizers, fibrates (PPAR gamma agonist) * Claustrophobia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Brain Glucose Uptake | 12 weeks | The investigators will assess brain glucose uptake using positron emission tomography at baseline and following 12-weeks of either aerobic exercise training or sedentary control period. |
Countries
United States
Outcome results
None listed