Neurosurgical Patients
Conditions
Brief summary
A previous study demonstrated topical lidocaine spray on the larynx and the trachea is effective in reducing hemodynamic response to laryngoscopy and endotracheal intubation. In clinical practice, blind oropharyngeal application of lidocaine without aiding direct laryngoscopy can not assured that sprayed lidocaine effectively reaches the larynx and trachea. Therefore, direct laryngoscopy should be necessary to reach topical lidocaine to correct sites. Unfortunately, direct laryngoscopy itself can affect hemodynamics during spraying lidocaine. In this study, we will investigate an effect of lidocaine sprayed on direct laryngoscopy and the tracheal mucosa on hemodynamic change throughout intubation.
Interventions
DRUGgroup C
0.9% normal saline was applied to trachea and laryngoscope blade
DRUGgroup L
10% Lidocaine was applied to the laryngoscope blade and 0.9% normal saline was applied to the trachea.
DRUGgroup V
0.9% normal saline was applied to the laryngoscope blade and 10% Lidocaine was applied on trachea.
DRUGgroup LV
10% Lidocaine was applied on laryngoscope blade and trachea.
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* aged 20-60 years, * ASA groups I or II
Exclusion criteria
* ASA III or IV, * hypertension, * anticipated difficult airway, and * severe coronary and cerebrovascular diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mean blood pressure, heart rate | baseline, at laryngoscope insertion, 60s after laryngoscope insertion, during intubation, one, two, three min after endotracheal intubation |
Countries
South Korea
Contacts
Primary ContactSUE YOUNG LEE, MD
Outcome results
None listed