Obesity
Conditions
Brief summary
There is a variability in weight loss after gastric bypass surgery for obesity despite a standardised surgical procedure. This study aims to investigate if genetic markers can predict outcome after gastric by-pass surgery in treatment of obesity. The investigators will also study if adenovirus infection can influence the outcome after surgery. In a subgroup of patients, hormonal changes after gastric by-pass surgery will be assessed. Lipid and protein patterns will be assessed in plasma and tissues. Omental and subcutaneous fat as well as liver biopsies and whole blood are stored in a biobank. The same tissues will be collected from non-obese controls undergoing gallbladder surgery.
Interventions
PROCEDUREGastric bypass or cholecystectomy
Sponsors
Danderyd Hospital
Ersta Hospital, Sweden
Karolinska University Hospital
Karolinska Institutet
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* laparoscopic gastric by-pass with BMI greater than 35
Exclusion criteria
* unable to understand swedish
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Genetic markers | day of surgery and 1 and 2 years after surgery | Blood samples and tissue biopsies taken at the time of surgery and at follow-up. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lipid and protein patterns in plasma and tissues | day of surgery and at 1 and 2 years postoperatively | Blood samples taken and tissue biopsies taken at the time of surgery and at follow-up |
| Previous viral infection | At time of surgery | Blood samples taken before surgery |
| Genexpression and comorbid disease | At time of bariatric surgery and 1-2 years postoperatively | Gene expression studies in tissue biopsies and whole blood at time of surgery and follow-up |
Countries
Sweden
Outcome results
None listed