Role of Prohepcidin in Uremic Patients

The Relationship of Prohepcidin Levels With Anemia and Inflammatory Markers in Non-diabetic Uremic Patients: A Controlled Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01735773

Enrollment

Registered

2012-11-28

Start date

2010-01-31

Completion date

2011-03-31

Last updated

2012-11-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease, Inflammation

Keywords

hemodialysis, inflammation, iron, peritoneal dialysis, prohepcidin, uremia

Brief summary

The investigators aimed to study the effect of prohepcidin levels on hematologic parameters and inflammatory markers in non-diabetic uremic patients. The investigators selected three groups of patients: Hemodialysis group, peritoneal dialysis group and the group with stage 4 chronic kidney disease. A control group was formed from healthy volunteers also. Each group has been planned to be formed of about 25 patients. Diabetic patients were excluded. Prohepcidin, hsCRP, IL-6, fibrinogen have been planned to be studied besides other routine biochemical analysis including hematological ones.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* hemodialysis and peritoneal dialysis patients who had been on dialysis therapy for more than 3 months, * age between 18-80 years, * patients with creatinine clearance between 15-30 ml/min.

Exclusion criteria

* age less than 18 or more than 80, * diabetic patients, * current active infectious or inflammatory disease.

Design outcomes

Primary

Measure	Time frame	Description
prohepcidin level	Six months	Prohepcidin levels will be compared with other inflammatory markers.

Secondary

Measure	Time frame	Description
Anemia and inflammatory markers	Six months	Correlations of prohepcidin levels with anemia and inflamatory markers

Countries

Turkey (Türkiye)

Outcome results