Cognitive Function
Conditions
Brief summary
The investigators performed a 12-week, randomized, double-blind, placebo-controlled human trial to evaluate the efficacy and safety of Eriobotyra Japonica Lindley Extract on improvement of Cognitive Function. The investigators measured improvement of Cognitive Function parameters , including K-MMSE, Ability to perform working memory tasks, CNT and BCRS, and monitored their blood pressure.
Interventions
DIETARY_SUPPLEMENTEriobotyra Japonica Lindley Extract
Eriobotyra Japonica Lindley Extract (1.5g/day)
DIETARY_SUPPLEMENTPlacebo
Placebo (1.5g/day)
Sponsors
Chonbuk National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
65 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* Males and females ≥ 65 years old * Able to give informed consent
Exclusion criteria
* History of underlying neurodegenerative disease such as Alzheimer's disease, and Parkinson's disease * Subjects with medical conditions such as Severe Dementia * Allergic or hypersensitive to any of the ingredients in the test products * History of reaction to any of the test products or of gastrointestinal diseases such as Crohn's disease or gastrointestinal surgery * History of alcohol or substance abuse * Participation in any other clinical trials within past 2 months * Laboratory test, medical or psychological conditions deemed by the investigators to interfere with successful participation in the study etc.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in K-MMSE(Korean Mini-Mental State Examination) | 12 weeks | K-MMSE(Korean Mini-Mental State Examination) was measured in study visit 1(0 week) and visit 3(12 week). |
| Changes in ability to perform working memory tasks | 12 weeks | Ability to perform working memory tasks was measured in study visit 1(0 week) and visit 3(12 week). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in CNT(Computerized neurocognitive function test) | 12 weeks | CNT(Computerized neurocognitive function test) was measured in study visit 1(0 week) and visit 3(12 week). |
| Changes in BCRS(Brief Cognitive Rating Scale) | 12 weeks | BCRS(Brief Cognitive Rating Scale) was measured in study visit 1(0 week) and visit 3(12 week). |
Countries
South Korea
Outcome results
None listed