Hypertension, Obesity, Resistant Hypertension, White Coat Hypertension
Conditions
Keywords
hypertension, obesity, white coat hypertension, resistant hypertension
Brief summary
The purpose of this study is to determine whether in pre-hypertensive and hypertensive states such as white coat hypertension, obesity related hypertension or resistant hypertension, renal function is more sensitive to orthostatic stress.
Interventions
Lower limbs are put in in LBNP device for one hour (-30 mbar)
DRUGCandesartan cilexetil
candesartan cilexetil 16 mg once a day for 7 days cross over with placebo in control group, obesisty group and white coat hypertension group
Sponsors
Swiss National Science Foundation
PD Dr. Grégoire Wuerzner
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI \> 30 Kg/m2 (obesity group) * office BP \>140/90 and daytime ambulatory blood pressure \<135/85 (white coat hypertension group) \_daytime abpm \>135/85 mm Hg or nighttime abpm 120/70
Exclusion criteria
* History of allergic reaction * Diabetes type 1 or type 2 * History of renal artery stenosis * Acute illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| sodium excretion | after one hour of lower body negative pressure | sodium excretion will be compared to control group (healthy volunteers) after one hour of lower negative pressure. The protocol includes 2 hours of baseline measure, one hour of lower negative pressure and 2 hours of recovery |
Secondary
| Measure | Time frame |
|---|---|
| glomerular filtration rate | after one hour of lower body negative pressure |
Other
| Measure | Time frame |
|---|---|
| renal plasma flow | after one hour of lower body negative pressure |
Countries
Switzerland
Outcome results
None listed