Chemotherapy Induced Oral Mucositis
Conditions
Keywords
Quercetin, Chemotherapy, Mucositis, Hematologic Malignancies
Brief summary
The study aims to evaluate the effect of Quercetin (a natural flavonoid) on prevention of and treatment of chemotherapy-induced oral mucositis in patients with blood malignancies.
Interventions
DRUGoral quercetin capsules
10 cases in case group and 10 cases in control group. Patients in the intervention group were administered two, 250 mg Quercetin capsules daily for 3 weeks. Patients in the placebo group received two placebo capsules containing lactose .Patients were examined every other day for evaluation of initiation and severity of oral mucositis.
DRUGPlacebo
Sponsors
Mashhad University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
15 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* patient under chemotherapy * for a hematologic malignancy * the hematologist permits the trial on the patient * agreement of patient for participating in the trial
Exclusion criteria
* presence pf ANY oral lesion at the beginning of the trial * loss of follow up * use of digoxin and cyclosporine * patient death
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| lower grade of mucositis | 3 weeks | grade of mucositis due to WHO criteria |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| duration of mucositis | 3 weeks of study tiem span and after trial | duration of mucositis due to Who criteria |
Countries
Iran
Outcome results
None listed