Crohn's Disease, Epidemiology, Korea, Ulcerative Colitis
Conditions
Keywords
Crohn's disease, ulcerative colitis, epidemiology, Korea
Brief summary
The purpose of this study is to evaluate the incidence, prevalence, clinical characteristics and prognosis of Crohn's disease and ulcerative colitis over time in a district of Seoul, Korea.
Detailed description
Inflammatory bowel disease (IBD), which is comprised of Crohn's disease (CD) and ulcerative colitis (UC) is a chronic inflammatory disease of gut with uncertain etiopathogenesis. According to our previous study (Yang, et al. Inflamm Bowel Dis 2008; 14: 542-549), the incidence and prevalence of IBD in Korea are still low compared with those in Western countries, but are rapidly increasing. However, the long-term trends of epidemiology of CD and UC together with their characteristics and prognosis in Korea are uncertain yet. The investigators therefore aim to elucidate the incidence and prevalence of CD and UC over a 30-year period, from 1986 to 2017, in the Songpa-Kangdong district of Seoul, Korea. In addition, the investigators also aim to reveal the clinical features at the time of diagnosis of IBD, long-term evolution of disease and prognosis.
Interventions
None listed
Sponsors
Kyung Hee University Hospital at Gangdong
Seoul National University Hospital
Seoul National University Bundang Hospital
Samsung Medical Center
Konkuk University Medical Center
National Police Hospital
Seoul Veterans Hospital
hansol hospital
Kangdong Seoul Clinic
Jamsil Seoul Surgical Clinic
Song Do Colorectal Hospital
Yang Hospital
Daehang Hospital
Kangdong Sacred Heart Hospital
Asan Medical Center
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Definite cases of CD and UC Patients are diagnosed with CD if they meet at least 2 of the following criteria: 1. clinical history of abdominal pain, weight loss, malaise, diarrhea, and/or rectal bleeding 2. endoscopic findings of mucosal cobblestoning, linear ulceration, skip areas, or perianal disease 3. radiologic findings of stricture, fistula, mucosal cobblestoning, or ulceration 4. macroscopic appearance of bowel wall induration, mesenteric lymphadenopathy, and creeping fat at laparotomy 5. pathologic findings of transmural inflammation and/or epithelioid granulomas Only patients who meet these criteria for at least 2 months are included. Patients are diagnosed with UC only if all 3 of the following criteria are present 1. a typical history of diarrhea or blood and pus or both in the stool for longer than 4 weeks 2. a typical sigmoidoscopic or colonoscopic picture with diffusely granular, friable, or ulcerated mucosa without rectal sparing or skip lesions or radiological signs of characteristic continuous granular or ulcerated mucosa 3. characteristic histopathological signs of inflammation on biopsy
Exclusion criteria
* IBD unclassified * Ethnic groups other than Korean
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence rate and prevalence rate of IBD | 1986-2017 (up to 31 years) | 1. Annual incidence rate of Crohn's disease and ulcerative colitis 2. Prevalence rate of Crohn's disease and ulcerative colitis as of Dec 31, 2017. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical features of patients with IBD | 1986-2017 (up to 31 years) | 1. Clinical characteristics of patients newly diagnosed with Crohn's disease or ulcerative colitis: gender, presenting symptoms, duration between symptoms to diagnosis, and phenotypes, etc. 2. Clinical course of patients newly diagnosed with Crohn's disease or ulcerative colitis: development of complications (strictures, perforations), intestinal resection rate, hospitalization rate, mortality, and pregnancies and their outcomes 3. Treatment modalities of IBD and their trends: use of medication (5-ASA, corticosteroids, immunomodulators, and biologic agents, etc.) |
Countries
South Korea
Contacts
Primary ContactSuk-Kyun Yang, M.D.
Backup ContactByong Duk Ye, M.D.
Outcome results
None listed