Blood Loss, Surgical
Conditions
Keywords
blood loss, burn, hemostasis
Brief summary
The standard of care for treatment of burn injury is to inject a solution of epinephrine under the skin of the injured site in order to reduce blood loss during skin grafting. This solution of epinephrine has been shown to have effects on the body outside the donor site. Some people have increases in heart rate and blood pressure. We will study the effect of a phenylephrine solution in place of an epinephrine solution to control blood loss. We think that phenylephrine will help decrease blood loss and not change blood pressure or heart rate. The injured area will be injected under the skin and a skin graft will be taken in the same way as we usually do. The only change will be the use of phenylephrine in the solution instead of epinephrine. Our goal is to find whether or not phenylephrine or epinephrine solution results in a reduction of blood loss without affecting the rest of the body.
Interventions
DRUGPhenylephrine
Sponsors
University of Manitoba
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
a) Burn injury requiring debridement and grafting between 5-30% TBSA
Exclusion criteria
1. Head and neck, hand, foot, or genital burns 2. On anticoagulants (except NSAIDs) 3. On monoamine oxidase inhibitor or tricyclic antidepressant 4. Coronary or peripheral vascular disease 5. History of arrhythmias 6. On a Beta-blocker 7. History of vascular abnormality 8. Hypertension
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean arterial blood pressure (MAP) | during first 30 minutes | Mean arterial blood pressure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood Pressure | q15 min | Cut off for safety: Diastolic \>140 or Systolic \>180; Recorded: * just prior to induction of anesthesia * maximum heart rate during time of procedure * minimum heart rate during time of procedure |
| Heart Rate | q15 min | Recorded: * just prior to induction of anesthesia * maximum heart rate during time of procedure * minimum heart rate during time of procedure |
Countries
Canada
Contacts
CONTACTJustin Gawaziuk, MSc
Outcome results
None listed