Carcinoma of Parotid Gland, Colon Rectal Cancer Tubulovillous Adenocarcinoma, Malignant Lymphoma of Lymph Nodes of Axillary, Malignant Lymphoma of Lymph Nodes of Inguinal Region, Malignant Lymphoma of Lymph Nodes of the Cervix, Tumor of Soft Tissue of Head, Face and Neck
Conditions
Keywords
spectroscopy, nerve, muscle, fat
Brief summary
Investigation of application possibilities of optical spectroscopy within the field of surgical resection procedures to spare nerve tissue. Optical spectroscopy enables the possibility to specifically differentiate between different (human) tissues. The hypothesis is that incorporation of this technique into existing medical devices (e.g. medical blade) would enlarge the accuracy and reliability of these devices. Sparing of nerve bundles during surgery can lead to decreased postoperative morbidity rates.
Detailed description
The aim of this pilot study is to prove that an investigational optical spectroscopy system can provide accurate identification of nerve tissue during surgery. Primary Objective: The goal of this pilot study is to evaluate whether optical spectroscopy is able to differentiate between nerve tissue and surrounding tissue. Secondary Objective: During the measurement procedure, possible improvements of the measurement hardware will be recorded and the handling of the optical spectroscopy system during surgery will be evaluated.
Interventions
PROCEDURESurgical resection
Patients planned for elective inguinal, axillary or cervical lymph node dissection or parotidectomy , patients with rectal cancer undergoing rectal surgery and patients undergoing resection of a soft tissue tumour.
Sponsors
Philips Electronics Nederland B.V. acting through Philips CTO organization
Philips Healthcare
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients planned for elective inguinal, axillary or cervical lymph node dissection or parotidectomy , patients with rectal cancer undergoing rectal surgery and patients undergoing resection of a soft tissue tumour. * Patients that have provided a signed informed consent * Patients ≥ 18 years old
Exclusion criteria
• Patients with suspected sensitivity to light; e.g. patients who have had photodynamic therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differentiation between nerve tissue and its surrounding tissue | Day 0 | Statistical analysis of the difference between diffuse reflectance spectra obtained at nerve tissue and its surrounding tissue measurement locations |
Countries
Netherlands
Outcome results
None listed