Arterial Wall Calcium Load in Pseudoxanthoma Elasticum

Arterial Wall Calcium Load and Preferential Sites in Pseudoxanthoma Elasticum Versus Type 2 Diabetes and Chronic Kidney Disease.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01731080

Acronym

Ca-Art-PXE2

Enrollment

Registered

2012-11-21

Start date

2012-01-31

Completion date

2013-07-31

Last updated

2012-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease, Pseudoxanthoma Elasticum, Type 2 Diabetes

Brief summary

Quantification and preferential sites of arterial wall calcification within the coronary and lower legs arteries will be comared between Pseudo-Xanthoma elasticum(PXE) atients and type 2 diabetics and Chronic Kidney disease.

Detailed description

In a previous work we have observed that patients suffering from PXE, a soft-tissue calcifying inherited autosomal disease, exhibited specific structural and functionnal features within the peripheral arteries. We now want to quantify and determine the preferential sites of the arterial wall calcification (Agatston score) between these patients compared to diabetics and patients with chronic renal insufficiency with mediacalcosis. All variables will be collected from a cohort of PXE monitored in our PXE Health and Care centre at the university hospital of Angers. Quantification of the arterial wall calcium load will be performed using helicoidal CT-scan. These variables will be compared to the same measurements performed in type 2 diabetic and chronic kidney disease patients paired by age and gender.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with phenotypically and genotypically-proven PXE * Type 2 diabetic patients with mediacalcosis (i.e. Ankle Brachial Index \> 1.30) * Patients with a chronic kidney disease (CKD), before kidney transplantation * All patients should be affiliated to a Health care system

Exclusion criteria

* Patient with unproved PXE * Patient under the age of 18 yrs * Patient unwilling to participate to the study * Pregnant women * Patient not affiliated to a Health care system

Design outcomes

Primary

Measure	Time frame	Description
calcification score	after inclusion	the level of arterial wall calcification determined by a Ct-scan and computed by the Agatston score

Secondary

Measure	Time frame	Description
site of calcification	after inclusion	the anatomical site of arterial wall calcification determined by a Ct-scan and computed by the Agatston score

Countries

France

Contacts

Primary ContactYannick LE CORRE, MD

yalecorre@chu-angers.fr33(2)41.35.39.10

Backup ContactLudovic MARTIN, MD, PhD

lumartin@chu-angers.fr33(2)41.35.34.19

Outcome results