Influence of Preload Dependence on the Effect of Phenylephrine on Cardiac Output

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01730820

Enrollment

Registered

2012-11-21

Start date

2012-11-30

Completion date

2013-07-31

Last updated

2014-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotension

Brief summary

The perioperative hemodynamic management aims to ensure organ perfusion pressure and an oxygen arterial transport adapted to oxygen consumption. Phenylephrine is the α-adrenergic agonist widely used during anesthesia for arterial pressure control. Several questions on phenylephrine global and regional hemodynamics effects remain unresolved. The investigators assume that Phenylephrine may decrease cardiac output by increasing the afterload, while most likely could also make an increase or a stability of cardiac output by action on the venous return. The investigators propose an observational study assessing the influence of preload dependence, defined by the values of pulse pressure variation, on the effect of phenylephrine on cardiac output, measured beat by beat by esophageal Doppler. The aim of the investigators work is to improve the understanding of phenylephrine action, a daily use therapeutic action, to improve the patients care.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Hypotension (SBP \<90 mm Hg and / or MAP \<60 mm Hg) * Injection of a bolus of phenylephrine at the discretion of the anesthesiologist physician in charge of the patient.

Exclusion criteria

* Minor or major patient under guardianship * Esophageal Diseases * supra ventricular rhythm trouble * Severe valvular * Shunt intracardiac * Vt \<7ml/kg theoretical weight * heart rate / respiratory rate \<3.6 * Clinical hypepression of intra-abdominal * Compliance \<30 mL/cmH2O * pulmonary hypertension, Right ventricular failure * Spontaneous Ventilation * Thorax open * VG severe dysfunction (LVEF \<40%) * Prior Injection of ephedrine prior

Design outcomes

Primary

Measure	Time frame	Description
cardiac output	one year	Comparing cardiac output values before and after injection of a phenylephrine bolus, based on the existence of a preload dependency, defined by a measure of respiratory variation of pulse pressure greater than or equal to 13%.

Countries

France

Outcome results