A Longitudinal Study in Parkinson's Disease (PD) Patients

A Longitudinal 5 Years Follow up Study in Parkinson's Disease (PD) Patients Carriers of the LRRK2 Gene G2019S Mutation

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01730599

Enrollment

200

Registered

2012-11-21

Start date

2012-11-30

Completion date

Unknown

Last updated

2012-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's Disease

Brief summary

This is a longitudinal study in patients with Parkinson's Disease (PD) carriers of a genetic mutation - substitution of gly with ser in position 2019 (G2019S) in the leucine-rich repeat kinase 2 (LRRK2) gene. The purpose of this study is to explore the association between genetic mutations in the known genes and their influence on disease manifestation over few years of follow up

Interventions

OTHERneurological exam

motor and cognitive functions

Study design

Observational model

COHORT

Eligibility

Sex/Gender

ALL

Age

30 Years to No maximum

Healthy volunteers

Inclusion criteria

* parkinson'd disease patients that already participated in a pasr cross sectional study

Exclusion criteria

* subjects with cognitive decline by the parameters defined in Diagnostic and Statistical Manual of Mental Disorders (DSM)- IV * subjects with psychiatric disorder * subjects unable to sign a consent form

Design outcomes

Primary

Measure	Time frame
change from baseline in updrs motor and total scores	the participants will be followed for 5 years. the measurements will be taken evry 18 month.

Countries

Israel

Contacts

Primary ContactAnat Mirelman, PhD

anatmi@tasmc.health.gov.il972-3-6973014

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026