Haemophilus Influenzae, Neisseria Meningitidis, Streptococcus Pneumoniae
Conditions
Brief summary
This study aims to provide an estimate of the proportion of suspected cases of bacterial meningitis that are due to N. meningitidis and the serogroup responsible in The Philippines and Vietnam.
Interventions
OTHERData collection
Collection of demographic data and vaccination history
OTHERCSF samples testing
CSF samples will be tested for the determination of N. meningitidis and other likely bacterial pathogens that cause bacterial meningitis (S. pneumoniae and H. influenzae)
Sponsors
GlaxoSmithKline
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Subjects who the investigator believes can and will comply with the requirements of the protocol or subjects who the investigator believes that parent(s)/Legally Acceptable Representative(s) \[LAR(s)\] can and will comply with the requirements of the protocol. * Written informed consent obtained from the subject/from the parent(s)/LAR of the subject. * A male or female subject who visits the hospital with suspected bacterial meningitis. * CSF sample taken as part of routine practice.
Exclusion criteria
* Child in care.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of N. meningitis in CSF samples | At enrollment (Day 0) |
| Serogroup of N. meningitis positive samples | At enrollment (Day 0) |
Secondary
| Measure | Time frame |
|---|---|
| Serotype of Streptococcus pneumoniae positive samples | At enrollment (Day 0) |
| Further characterization of N. meningitidis using Multi Locus Sequence Typing | At enrollment (Day 0) |
| Total number of subjects with suspected bacterial meningitis (according to diagnostic criteria used by each participating hospital to identify this condition) | At enrollment (Day 0) |
| Further classification of Haemophilus influenzae positive samples into Type B and non-B Types | At enrollment (Day 0) |
| Prevalence of Haemophilus influenzae and Streptococcus pneumoniae in CSF samples as causes of bacterial meningitis | At enrollment (Day 0) |
Countries
Philippines, Vietnam
Outcome results
None listed