Fluid Investigation Colloid vs Crystalloid Reg. Renal Hemodynamics and Function

Colloid vs Crystalloid Infusion Postoperative in CABG Patients Regarding Renal Hemodynamics and Function

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01729364

Enrollment

Registered

2012-11-20

Start date

2008-04-30

Completion date

2014-12-31

Last updated

2015-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal Impairment

Keywords

elective CABG, renal impairment, GFR, renal blood flow, colloid, crystalloid, thermodilution technique, oxygen supply demand

Brief summary

Comparing the effects of crystalloid versus colloid fluid resuscitation in CABG patients postoperatively regarding renal blood flow, glomerular filtration rate and renal oxygen demand.

Detailed description

Due to blood loss and SIRS postoperative hypovolemia is a usual feature after CABG surgery. Substantial controversy persists regarding the best choice of fluid to be used for resuscitation in this setting regarding renal function and oxygen supply-demand matching. In our study we aim to investigate differences in functional renal parameters by dividing patients postoperatively in two groups, substituted either with crystalloid fluid, Ringer-Acetat, 20 ml/kg or colloid, HES 6% (130/0,4) 10 ml/kg under 20 minutes. Central and renal hemodynamics will be measured before (baseline) and after fluid administration by blood sampling and thermodilution in both pulmonary artery catheter and renal vein catheter. Measurement endpoints will mainly consist of central hemodynamics, renal blood flow, GFR and renal oxygen extraction rate which we aim to compare between groups.

Interventions

DRUGcrystalloid

DRUGcolloid

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* elective fast track CABG patients, postoperative

Exclusion criteria

* hemodynamic instability * preoperative renal impairment * major postoperative bleeding

Design outcomes

Primary

Measure	Time frame	Description
Change from baseline and differences inbetween groups in glomerular filtration rate, measured at different timepoints	125min after baseline-measures	GFR measured by thermodilution and blood- and urine sampling baseline1 (0min), baseline2 (+30min), timepoint1 (+65min), tp2 (+85min), tp3 (+105min), tp4 (+125min)

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 15, 2026