Patient Compliance
Conditions
Brief summary
The purpose of this study is to assess exercise performance in 20 healthy children 10-19 years of age with a body mass index greater than 85th percentile and to evaluate the effect of dietary and exercise intervention over 12 weeks.
Detailed description
Our hypothesis is that the vascular health in these children will improve at the end of intervention. The results of this study will help us in our long-term objective of improving vascular health of children with congenital/acquired heart disease, a group particularly at risk for premature atherosclerosis.
Interventions
Remote Dietary and Exercise Intervention Program
Sponsors
Stanford University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
10 Years to 19 Years
Healthy volunteers
Yes
Inclusion criteria
* 10-19 years old * Overweight (BMI \> 85 percentile) * Interested in a 12 week ¬home exercise & nutrition program * Have computer & internet access * Can come to Lucile Packard Children's Hospital at Stanford for a 3-hour test at the start & end of the study (so only twice!) * Are able to come to testing after fasting overnight * Do not smoke * Do not take any medications
Exclusion criteria
* non-overweight adolescents
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vascular Health | Beginning of 12th week and end of 12th week | Tests will include: EndoPAT analysis to assess endothelial function, applanation tonometry to assess arterial stiffness, carotid artery imaging to assess the wall thickness of the carotid arteries, exercise testing to assess the physical exercise capacity of these children and blood work to evaluate the lipid profile and inflammation status (CRP). The participant will be asked to come in after an overnight fast. They will receive a snack bag before the exercise test. |
Countries
United States
Outcome results
None listed