Effects of Dietary Nitrate on Age-related Vascular Function

Effects of Dietary Nitrate Supplementation on Age-related Vascular Dysfunction

Status

Completed

Phases

Phase 1Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01729234

Enrollment

Registered

2012-11-20

Start date

2012-10-31

Completion date

2013-05-31

Last updated

2013-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endothelial Dysfunction

Keywords

age related Endothelial Dysfunction

Brief summary

Purpose of the study is to characterize the chronic effect of dietary nitrate on vascular function in healthy volunteers with particular emphasis on age-related alterations.

Interventions

DIETARY_SUPPLEMENTNitrate

Dietary Supplement

DIETARY_SUPPLEMENTPlacebo

Dietary Supplement

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

55 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

\>55 Years Healthy

Exclusion criteria

known cardiovascular disease

Design outcomes

Primary

Measure	Time frame	Description
Endothelial function measured by flow-mediated dilation (FMD)	30 days	The effect of dietary nitrate on endothelial function as measured by flow-mediated dilation (FMD) after forearm ischemia and reperfusion.

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026